Dynamics of the plasma-interstitial fluid distribution and transcapillary pressure difference.

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Abstract
The relationship between the effective intracapillary pressure and the effective pericapillary pressure following blood withdrawal and retransfusion was studied. Change in the effective pericapillary pressure was estimated from the transcapillary pressure difference determined from the amount of transcapillary fluid shift and the effective intracapillary pressure. The estimated alteration in the effective intracapillary ranged from 1-7 mmHg in blood withdrawal and retransfusion (15% of estimated blood volume). The transcapillary pressure difference or effective pressure gradient for fluid movement between intracapillary and pericapillary space, as within .apprx. 0.5 mmHg when the whole body filtration coefficient was used. The effective pericapillary pressure closely followed the effective intracapillary pressure. Change in intracapillary pressure elicits a rapid shift of vascular or interstitial fluid and the effective pericapillary pressure equilibrates rapidly with the intracapillary pressure.