Transient Intestinal Ischaemia Induced by Degradable Starch Microspheres: Experiments in the cat

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Abstract
Temporary ischemia was induced in cat small intestine by degradable starch microspheres. Regional arterial and tissue blood flow immediately fell by 85% with subsequent normalization within 26 min after microsphere injection. Degraded 99Tcm-labeled microspheres were exponentially removed from intestinal vessels and accumulated in the liver. Provided near-total arteriolar obstruction is induced, external isotope detection may permit assessment of the duration of the induced ischemia, which implies a selection of the appropriate time for tumor radiation therapy.