Double-Helical Polynucleotides: Immunochemical Recognition of Differing Conformations
- 7 August 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3945) , 609-611
- https://doi.org/10.1126/science.169.3945.609
Abstract
Rabbit antibodies to double-helical RNA react by complement fixation with synthetic or natural double-strand RNA but not with native DNA. In turn, human (from systemic lupus erythematosus patients) antibodies to native DNA do not react with double-strand RNA. Both types of antibodies show cross-reactions (from 1 percent to 50 percent) with RNA-DNA hybrids, but antibodies to the hybrids do not react at all with double-strand RNA or with native DNA. Antibodies to polydeoxyguanylate·polydeoxycytidylate also failed to react with native DNA.Keywords
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