TOXICITY OF MITOMYCIN-C AND ANTI-INTOXICATION BY FUMARIC-ACID IN LIVER AND KIDNEY CELLULAR FINE-STRUCTURE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 73  (4) , 656-660
Abstract
The toxic symptoms in ICR mice given 2 i.p. injections of 4 mg/kg of [the antineoplastic drug] mitomycin C at an interval of 48 h were reduced by the concurrent administration of 40 mg/kg of fumaric acid. The changes of subcellular components and organelles in the liver and kidney at 4 days after the 2nd injection are described. The liver treated with mitomycin C showed perinuclear irregularity, aggregation of chromatins and abnormal cytoplasmic organelles (e.g., swelling of mitochondria and dilatation of rough endoplasmic reticulum). Focal localization of rough endoplasmic reticulum was noted. The concurrent administration of fumaric acid reduced the incidence of such deleterious changes. Increases in the number of nucleoli and normal cytoplasmic organelles were evident. The kidney treated with mitomycin C showed decrease of chromatins and edematous nuclear matrix. The cytoplasmic organelles were swollen. The action of fumaric acid against mitomycin C intoxication was more apparent in the kidney. Chromatins and nucleoli developed well; other subcellular organelles appeared completely normal.