SHORT-LIVED, DIVIDING CELLS MEDIATE ADOPTIVE TRANSFER OF IMMUNITY TO TRICHINELLA-SPIRALIS IN MICE .1. AVAILABILITY OF CELLS IN PRIMARY AND SECONDARY INFECTIONS IN RELATION TO CELLULAR-CHANGES IN THE MESENTERIC LYMPH-NODE

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 46  (2) , 443-450
Abstract
After a primary infection with the parasitic nematode T. spiralis, NIH mice showed a short lived increase in cellularity of the mesenteric lymph node (MLN), which began between days 2-4, peaked at day 8 and had declined by day 12. The majority of cells contributing to this increase were Ig-negative and were presumed to be T cells. Coincident with the increase in cell number there was an increase in lymphoblast activity, again largely in the T-cell fraction. MLN cells taken at intervals from mice during a primary infection successfully transferred immunity, i.e., accelerated worm expulsion in recipients, on days 4 and 8, but not on day 13. The effective cells in transferring immunty were present in the T-enriched fraction. When mice were given a 2nd infection 21 days after a primary infection the same sequence of changes was apparent in the MLN, but the time course was accelerated, i.e., peak cellularity and lymphoblast activity occurred on day 4 post challenge. Cells capable of transferring immunity were present in the MLN on days 2 and 4 post challenge but not thereafter. As in the primary infection the effective cells, and those responsible for the cellular changes in the MLN, were T cells.

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