Effect of 2,4-Dinitrophenol Upon Anaerobic Glycolysis in Rat Cerebral Cortex Slices

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Abstract
Over a wide concn. range 2,4-dinitrophenol (DNP) has no effect upon the rate of anaerobic glycolysis in rat cerebral cortex slices as measured manometrically and chemically. Very high concns. are inhibitory. It was not possible to demonstrate the augmenting action of DNP on anaerobic glycolysis in frog muscle. These findings are discussed with relation to the possible correlation of temp. regulation and metabolic activity of the central nervous system.