EFFECT OF THYROIDECTOMY, THIOUREA AND IODINE ON THE DERMAL ACID MUCOPOLYSACCHARIDES AND THE MAST CELLS IN RATS

Publisher Website
Google Scholar
Abstract
Thyroidectomy and, to a lesser extent, thiourea increased the dermal acid mucopolysaccharides, while I produced no change in normal animals, thyroidectomized animals or those treated thiourea. Histochemical control, based on metachromatic staining with thionin at pH 3.2, and digestion with ptyalin and hyaluronidase were in complete agreement. The number of mast cells in the skin was related to the mucopolysaccharide concentration. In bone marrow smears, however, the normal level of mast cells was not altered in animals receiving thiourea or in thyroidectomized animals receiving I, whereas it was reduced in thyroidectomized animals and in normal animals receiving I.