Fate and Distribution of Fe59 Labelled Ferrocyanide in Humans and Dogs.

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Abstract
The fate and distribution of Fe59 tagged ferrocyanide were evaluated in humans and dogs. The tracer could not be detected in red blood cells, gastric juice, saliva or feces. The apparent volume of distribution of the tagged ferrocyanide was frequently smaller than the assumed extra-cellular space and in 3 instances was less than the simultaneously measured inulin space. In vitro binding to plasma albumin was demonstrated by electrophoretic and protein precipitation techniques. Because of its binding to plasma protein and rapid excretion by the kidneys, radioactive ferrocyanide is considered unsuitable as a measure of extracellular fluid.