Initial Distribution and Fate of Ferrocyanide in Dogs

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Abstract
A method for the measurement of ferrocyanide ion in plasma and urine was evaluated. Studies of the fate of intravenously injected ferrocyanide demonstrated the following: (a) from 94-98% of the given ion was recovered in the urine in 24 hours. (b) Ferrocyanide could not be detected in red blood cells, gastric juice or feces. (c) Its apparent volume of distribution at 1-5 hours always exceeded that of inulin, with a mean difference of approximately 5% of body weight, and probably more closely approximates the volume of extracellular fluid. (d) The unreliability of the extrapolation techniques to estimate the volume of extracellular fluid when using rapidly excreted indicators was discussed.