Alterations in Aorta Lipids with Advancing Atherosclerosis

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Abstract
Analysis by silicic acid chromatography of the lipids of the intima and media of aortas with progressive stages of atherosclerosis reveals an increase in sterol and sterol ester fractions and a decrease in phospholipids. It is proposed that these changes reveal a very low rate of lipid turnover in this tissue. The fatty acid composition of the cholesterol esters, as measured by gas-liquid chromatography, did not change with advancing atherosclerosis.