Reversible Heat-Induced Dissociation of the Alpha-Casein Complex

Abstract
Sephadex gel filtration and ultracentrifugation at temperatures up to 85[degree] C demonstrated a reversible heat-induced dissociation of the [alpha]-casein complex into [alpha]s1-casein and k-casein, which occurred between 45 and 54[degree]C. Presumably, the dissociation is the result of a transition from predominantly hydrophilic interactions (hydrogen bonds) between [alpha]s1- and k-casein at low temperature to hydrophobic interactions involving only k-casein at elevated temperature.

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