Perfusion of cat brain with simplified blood after filtration through glass wool

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Abstract
"Simplified blood," consisting of very well-washed bovine red cells suspended in an albumin-Ringer solution was used to perfuse the vascularly isolated cat brain (36 experiments). In the majority of experiments there was a progressive rise in cerebral vascular resistance during 1 hr. of perfusion. In a second series (31 experiments), filtration of simplified blood through glass wool prevented this rise in cerebral vascular resistance. The initial perfusion pressure was significantly lower with filtered as compared to nonfiltered blood and some cerebral metabolic processes were modified as a result of filtration. The results of one experiment are reported in which defibrinated ox blood was filtered through glass wool and then perfused through the cat brain.