GASTRIC INHIBITION CAUSED BY AMINO ACIDS IN THE SMALL INTESTINE

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Abstract
Sixteen amino acids were studied to determine whether they caused gastric inhibition when placed in the small intestine of unanesthetized, fistula dogs. Only the monoamino-monocarboxy acids caused gastric inhibition regularly when administered in neutral soln. The inhibitory effect of these acids was roughly proportional to their molecular wts. but the evidence indicates that it was also influenced by other factors. The dicarboxy acids and the diamino acids caused gastric inhibition when administered as free acids without neutralization but were ineffective in neutral soln. Expts. designed to determine whether the dicarboxy and diamino acids owe their gastro-inhibitory activity to acidity and alkalinity, respectively, or to their amino acid structure were inconclusive.

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