Detection and identification of some metabolites of isonicotinic acid hydrazide (isoniazid) in human urine

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Abstract
Methods are descr. for detecting and identifying some tertiary pyridine compounds, in particular pyridine-4-carboxy derivatives. The probable identities of 2 metabolites excreted in urine by human subjects treated with isoniazid, pyridine-4-carboxyhydrazide,were established as isonicotinoylglycine and isonicotinic acid. Large amts. of unchanged isoniazid were not excreted.