The Renal Excretion of Oxypurines*

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Abstract
The renal clearance of oxypurines (xanthine and hypoxanthine) was measured in humans by standard techniques. Relatively low values were observed at endogenous plasma oxypurine concentrations. When these concentrations were increased, by direct transfusion or by allopurinal therapy, oxypurine/inulin clearance ratios increased considerably and at times exceeded 1.0. A patient with xanthinuria cleared oxypurines at a normal rate when allowance was made for her high endogenous plasma oxypurine concentration. Uricosuric agents were found to reduce oxypurine excretion in a patient with xanthinuria and in a subject who was receiving allopurinol.