Distinct forms of both alpha and beta subunits are present in the human Ia molecular pool.

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Abstract
Two distinct subsets of human Ia molecules, NG1 and NG2, present in all individuals irrespective of their HLA-DR phenotype, which were previously defined by their reactivity with 2 [mouse] monoclonal hydridoma antibodies, D1-12 and D4-22, were analyzed by 2-dimensional peptide mapping techniques. In the Ia molecular pool from a single individual, small .beta. subunits of the NG1 and NG2 subsets display significant differences from each other. .beta. subunits of the same subset from 2 different allotype Ia molecular pools are also different from each other, thus indicating that NG1 and NG2 subsets carry polymorphic specificities. Large .alpha. chains of NG1 and NG2 subsets are different from each other; no significant differences are observed in .alpha. chains of the same subset when different allotype Ia pools are analyzed. The possible genetic implications of these findings are discussed.