CORTISONE TREATMENT OF THE ADRENOGENITAL SYNDROME WITH SPECIAL REFERENCE TO STEROID EXCRETION DURING CONTINUED AND DISCONTINUED THERAPY

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Abstract
Case reports were given on 2 boys and 2 sisters with adrenogenital syndrome caused by adrenocortical hyperplasia. They were treated with cortisone for 9-15 months. A satisfactory inhibiting effect was obtained in all. In the girls, therapy was discontinued after 7 months. Five months later, excretion of 17-KS (Keto-steroids) had not exceeded 1/3 of the pretreatment levels in the 6-year-old girl, and in the 4-year-old girl, it first exceeded normal values after 12 months without therapy. In the girls, temporary but considerable elevations were seen in excretions of corticoids without a simultaneous corresponding increase in 17-KS excretion during the treatment and for a couple of months after cessation of treatment.