THE FATE OF BRANCHED-CHAIN FATTY ACIDS IN ANIMAL BODY. IV. A CONTRIBUTION TO THE MODE OF BIOLOGICAL BREAKDOWN OF NATURALLY OCCURRING FATTY ACIDS*
- 1 November 1950
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 37 (3) , 343-353
- https://doi.org/10.1093/oxfordjournals.jbchem.a126203
Abstract
In order to elucidate the mechanism of oxidation of fatty acids in vivo, rabbits were injd. with 2 branched-chain fatty acids, 2-propyl-myristic acid (C17), and 2-propyltridecanoic acid (C16), respectively. In the 1st instance, the diabasic acid 2-propyladipic acid (C9) was isolated from the urine, in the 2d instance a mixture of 2-propyl-glutaric acid (C8) and 2-propylpimelic acid (C10)-According to these findings the fatty acid chain 1st undergoes [omega]-oxidation to dibasic acid, followed by repeated beta-oxidation, which, e.g., in the case of 2-propylmyristic acid occurred 4 times and thus shortened the chain by 8 C.This publication has 6 references indexed in Scilit:
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