Role of Epinephrine in the Physiology of Fat Mobilization

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Abstract
The development of a fatty liver which follows the admn. of ethionine to fasted female rats was found to be inhibited by adrenalectomy. Even large amts. of cortisone when administered alone did not completely restore the ability of the adrenalectomized rat to mobilize fat, although small amts. did so when combined with epinephrine. Ergotamine treatment of normal animals and adrenal demedullation reduced fat mobilization to levels observed in totally adrenalectomized rats. Admn. of epinephrine to adrenal demedullated rats re-stored to normal their ability to develop a fatty liver following ethionine admn.