AN ACCELERATING PROPERTY OF PLASMA FOR THE COAGULATION OF FIBRINOGEN BY THROMBIN 12

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Abstract
The thrombin time, that is, the clotting time of a mixture of oxalated and bovine thrombin, was prolonged in patients with liver disease, multiple myeloma, eclampsia and severe pre-eclampsia. The thrombin time was also prolonged in normal plasma stored at 4[degree] C for several months. The prolonged thrombin time under all these conditions was shortened by defibrinated normal plasma. The factors responsible for this acceleration of the coagulation of fibrinogen were non-dialyzable heat labile and concentrated in the fraction of plasma precipitated between 33 and 60% ammonium sulfate. The accelerating effect was probably executed indirectly, since plasma or its fractions did not accelerate the clotting of human or bovine fibrinogen.