THE FORMATION OF ANTIGONADOTROPHIN IN SHEEP AND ITS EFFECT ON THE ENDOCRINES AND REPRODUCTIVE SYSTEM

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Abstract
Eight female sheep were treated twice weekly with various doses of equine gonadotrophin injected either subcutaneously or intravenously. Antigonadotrophic activity appeared by the second week with injections of 200 IU, by the third week with 500 IU, and by the fifth week with the highest dose (1000 IU). In the last case, maximum activity was delayed until the 7th week. Route of injection did not influence rate of formation. When injections were discontinued, the antigonadotrophic potency of the serum was reduced after three weeks, but the levels again rose rapidly upon resumption of treatment, soon equaling or exceeding the former levels. Prolonged administration of gonadotrophin did not influence the weights of the pituitary gland, adrenal, thyroid, or ovaries. When large doses of equine gonadotrophin (500 or 1000 IU) were injected twice weekly, the ovaries remained acyclic and pituitary LH content was significantly reduced.