STUDIES ON ANTIGONADOTROPHINS WITH EMPHASIS ON THEIR FORMATION IN CATTLE

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Abstract
Fourteen cattle were injected with pregnant mare''s serum gonadotropin (PMS) to determine the effect of dosage and frequency of injection upon the production of antigonadotropins. Daily injections of 1430 I.U. of PMS over 2 months were more effective than large (10,000 I.U.) weekly dosages and the small dosages caused very littly antihormone formation. A 2d series of injections following a pause of 2 months resulted in a more rapid and greater anti-hormonal formation. In the concentrations occurring in the cattle sera tested, no evidence of precipitating antibodies was found. Progonadotropic activity was demonstrated against pituitary gonadotropic extracts whereas only suggestive evidence against PMS was obtained.