Serum lipids and apolipoproteins in children with Type 1 (insulin-dependent) diabetes during the first two years of the disease

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Abstract
Serum lipoproteins and apolipoproteins were studied at diagnosis and 6,12 and 24 months later in 30 consecutive children aged 3–15 years with newly detected Type 1 (insulin-dependent) diabetes mellitus (December 1982–October 1984) and in 44 healthy control children. Serum triglycerides at diagnosis were significantly higher than after 6–24 months and also higher than in the control group (ppppppp1c and the concentrations of the very low density lipoproteins and the low density and high density lipoprotein triglycerides. There were also significantly positive correlations (p1c and apolipoprotein A-I and apolipoprotein B respectively. After treatment these correlations disappeared, except for a positive correlation with very low density lipoprotein triglycerides at 2 years. In conclusion, at diagnosis, when the diabetic children were in an insulin-deficient state, all apolipoproteins and serum lipoprotein fractions, except cholesterol in high density lipoproteins and low density lipoproteins were increased. During the first two years of treatment the concentrations of lipoproteins and apolipoproteins in serum are similar to those in healthy children.