AN ASSAY FOR SCREENING DRUGS AGAINST ANIMAL-INFECTIVE BLOOD-STREAM FORMS OF TRYPANOSOMA-BRUCEI-BRUCEI INVITRO
- 1 January 1985
- journal article
- research article
- Vol. 11 (3) , 155-161
Abstract
A rapid and simple assay for in vitro drug screening was established using the mammalian feeder layer cell system for continuous cultivation of infective bloodstream forms of T. brucei brucei. A total of 21 trypanocides were tested. Differences in sensitivity to standard trypanocides were detected among drug-susceptible isolates and strains of T. b. brucei. This assay may thus be of potential use for rapid detection of new drug-resistant isolates of T. b. brucei. [Trypanosomiasis in livestock represents a problem of vital importance for the rapidly expanding human population on the African continent.].This publication has 7 references indexed in Scilit:
- Trypanocidal action of neuroleptic phenothiazines in Trypanosoma bruceiMolecular and Biochemical Parasitology, 1983
- Antitrypanosomal Activity of SinefunginThe American Journal of Tropical Medicine and Hygiene, 1983
- Polyamine Metabolism: A Potential Therapeutic Target in TrypanosomesScience, 1980
- In vitro cloning of animal-infective bloodstream forms of Trypanosoma bruceiParasitology, 1980
- Heme lysis of the bloodstream forms of trypanosoma bruceiBiochemical Pharmacology, 1977
- African Trypanosomes: Cultivation of Animal-Infective Trypanosoma brucei in VitroScience, 1977
- Inhibition of the respiration of Trypanosoma rhodesiense by thiolsBiochemical Journal, 1956