Short Communication: The involvement of DNA topoisomerases in DNA repair and mutagenesis
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 2 (2) , 157-160
- https://doi.org/10.1093/carcin/2.2.157
Abstract
DNA topoisomerase II (DNA gyrase) is the enzyme which inserts negative supercoils into double-stranded DNA. In this paper it is shown that both subunits of this enzyme, and one subunit of the related DNA topoisomerase II' are involved in the repair of u.v.-induced damage and in u.v.-induced mutagenesis.This publication has 18 references indexed in Scilit:
- Promoter-specific inhibition of transcription by antibiotics which act on DNA gyraseNature, 1978
- Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage lambda.Proceedings of the National Academy of Sciences, 1978
- Mode of Incomplete Cross-Resistance Among Pipemidic, Piromidic, and Nalidixic AcidsAntimicrobial Agents and Chemotherapy, 1978
- Involvement of supertwisted DNA in integrative recombination of bacteriophage lambdaJournal of Molecular Biology, 1978
- Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activityProceedings of the National Academy of Sciences, 1978
- Nalidixic acid resistance: A second genetic character involved in DNA gyrase activityProceedings of the National Academy of Sciences, 1977
- Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzymeProceedings of the National Academy of Sciences, 1977
- Role of DNA gyrase in phiX replicative-form replication in vitro.Proceedings of the National Academy of Sciences, 1977
- Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.Proceedings of the National Academy of Sciences, 1976
- DNA gyrase: an enzyme that introduces superhelical turns into DNA.Proceedings of the National Academy of Sciences, 1976