A COMPARISON OF SKELETAL UPTAKES OF 3 DIPHOSPHONATES BY WHOLE-BODY RETENTION - CONCISE COMMUNICATION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 22  (10) , 880-883
Abstract
Twenty normal [human] volunteers had measurements of 24 h whole-body retention (WBR) of 3 structurally related Tc-99m-labeled phosphonate skeletal imaging agents: (1-hydroxyethylidene) diphosphonate (HEDP), methylene diphosphonate (MDP) and hydroxymethylene diphosphonate (HMDP). The average WBR values, reflecting skeletal uptake, were 18.4, 30.3 and 36.6%, respectively. Slight alterations in diphosphonate molecular structure have a significant effect upon specificity for osseous tissue and thus may affect skeletal image quality and the usefulness of the WBR technique in diagnosing metabolic bone disease.