Phenytoin interacts with calcium channels in brain membrances
- 1 November 1984
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 16 (5) , 616-617
- https://doi.org/10.1002/ana.410160514
Abstract
Phenytoin at concentrations of between 30 and 300 μM inhibited binding of the calcium antagonist {3H} nitrendipine to voltage‐dependent calcium channels in brain membranes. Other anticonvulsants (phenobarbital, carbamazepine, valproic acid, and clonazepam) failed to inhibit binding or did so only at concentration much higher than occur clinically. Calcium channel blockade may be important in the clinical actions of phenytoin, including certain of the adverse effects of the drug.Keywords
This publication has 9 references indexed in Scilit:
- A unitary mechanism of calcium antagonist drug action.Proceedings of the National Academy of Sciences, 1983
- Barbiturate reduction of calcium-dependent action potentials: Correlation with anesthetic actionBrain Research, 1982
- Calcium uptake mechanisms affected by some convulsant and anticonvulsant drugsBrain Research, 1981
- Benzodiazepine Receptor: Demonstration in the Central Nervous SystemScience, 1977
- Efficacy of intravenous phenytoin in the treatment of status epilepticus: Kinetics of central nervous system penetrationAnnals of Neurology, 1977
- REGULATION OF THE LEVEL OF ENDOGENOUS PHOSPHORYLATION OF SPECIFIC BRAIN PROTEINS BY DIPHENYLHYDANTOIN1Journal of Neurochemistry, 1977
- Anticonvulsant Drug MechanismsArchives of Neurology, 1976
- Diphenylhydantoin and Calcium Movement in Lobster NervesArchives of Neurology, 1974
- Diphenylhydantoin and CalciumArchives of Neurology, 1973