COMPOUNDS WITH POTENTIAL ANTITUMOR-ACTIVITY .4. SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF 1-ARYL-N,N-DI-[2-(1,3,4-THIADIAZOLYL)]METHYLENEDIAMINE
- 1 September 1986
- journal article
- research article
- Vol. 41 (9) , 713-721
Abstract
Some 1-aryl-N,N''-di[2-(1,3,4-thiadiazolyl)]methylenediamines were synthetized and tested against lymphocytic murine leukemia P 388. Compounds (1)-(III), (VIII)-(XII) and (XVIII)-(XIX) showed significant by prolongation the survival time of tumor-bearing mice (T/C% 129-194).This publication has 3 references indexed in Scilit:
- Antitumor activity of 2-acylamino-1,3,4-thiadiazoles and related compounds.CHEMICAL & PHARMACEUTICAL BULLETIN, 1982
- Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compoundsJournal of Medicinal Chemistry, 1979
- THE ANTILEUKEMIC ACTION OF 2 THIADIAZOLE DERIVATIVES1960