EFFECT OF KALMEGH EXTRACT ON RAT-LIVER AND SERUM ENZYMES

  • 1 January 1983
    • journal article
    • research article
    • Vol. 5  (10) , 727-730
Abstract
Oral administration of Kalmegh [Andrographis paniculata] extract under acute (single dosage) and sub-acute (for 7 and 15 consecutive days) conditions at a dosage of 0.5 g dry leaf/kg per day to adult rats produced no change in the activities of glutamate oxaloacetic transaminase (GOT) and glutamate pyruvic transaminase (GPT) in liver and serum. Administration of ethyl alcohol at a dosage of 0.2 g/kg per day (oral) for 7 and 15 consecutive days produced an appreciable increase in liver GOT and GPT activities. No appreciable change in serum GOT and GPT activities was observed under a similar condition of treatment. Oral administration of a high dosage of ethyl alcohol (3 g/kg per day) produced a significant increase in the activities of serum enzymes only. This alcohol-induced increase in serum transaminase activity became normal with pre- and post-treatment of Kalmegh extract (0.5 g/kg per day). Kalmegh extract apparently protects the alcohol-induced toxic effect in liver tissue.