Subcellular Distribution of the Tumor-Specific Transplantation Antigen of Simian Virus 40-Transformed Cells
- 1 October 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 59 (4) , 1291-1295
- https://doi.org/10.1093/jnci/59.4.1291
Abstract
TU-5, a simian virus 40 (SV40)-transformed cell line of BALB/c origin, expressed the SV40-specific T-antigen and a transplantation antigen (TSTA). Nuclei and plasma membranes were prepared from these cells and shown on the basis of the distribution of T-antigen and histocompatibility (H-2) antigens to be relatively free of cross contamination. Most of the TSTA, estimated by tumor rejection, was associated with the nuclear fraction.Keywords
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