The First Asymmetric Intramolecular Stetter Reaction. Preliminary Communication
- 25 October 1996
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 79 (7) , 1899-1902
- https://doi.org/10.1002/hlca.19960790712
Abstract
The first asymmetric intramolecular Stetter reaction is reported, using the chiral triazolium salt 1 as catalyst. Starting from the easily accessible 4‐(2‐formylphenoxy)but‐2‐enoates 2, this protocol opens up an enantioselective pathway to the benzo‐annulated pyran‐4‐ones (chroman‐4‐ones) 3a–h with good yields and enantiomeric excesses of up to 74%.Keywords
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