Multiple sclerosis
- 1 October 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 35 (10) , 1443
- https://doi.org/10.1212/wnl.35.10.1443
Abstract
We found free light chains in the CSF of 18 MS patients, but not in any of 14 patients with other neurologic disease. CSF from all MS patients contained kappa and lambda chain dimers, less frequently contained light chain monomers, and never contained free gamma heavy chains. Light chains were not detected in matched serum samples. CSF from MS patients did not release free light chains from whole IgG in CSF of controls. The findings suggest that these free light chains originate in plasma cells, not from degradation of whole IgG.This publication has 15 references indexed in Scilit:
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