Salicylate hypoprothrombinemia in rheumatoid arthritis with liver disease. Report of two cases

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Abstract
Two patients with rheumatoid arthritis and an undefined liver disease who developed hypoprothrombinemia and bleeding in conjunction with the administration of salicylates in usual anti-inflammatory doses are presented. The effects of rheumatoid arthritis on the liver, the patho-genesis of bleeding following salicylate administration, and the possible detrimental association of the two are discussed. A sulfobromophthalein (BSP) and prothrombin time obtained prior to salicylate therapy in patients with severe rheumatoid arthritis may avert the rare but dangerous hazard of hypoprothrombinemia.

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