RELATIVE CHOLINERGIC EFFECTS OF SELECTED ESTROGENS
- 30 November 1939
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 128 (1) , 147-153
- https://doi.org/10.1152/ajplegacy.1939.128.1.147
Abstract
The conc. of acetylcholine in the uterus of an ovariectomized rabbit is 0.065 7 per g. of fresh tissue. Each of the native estrogens increased the quantity of acetylcholine within one hr. to over 0.420 [gamma] per g. of fresh uterus. Triphenyl ethylene was similarly effective, stilboestrol was not. The esters of estra-diol were equally prompt in their cholinergic actions. Consequently, the cause of the delayed estrous response of the uterus to estrogens lies subsequent in time to the initial cholinergic effect and not to delayed absorption. Moreover, since stilboestrol is highly estrogenic but not appreciably cholinergic, the estrous response of the uterus does not depend upon the initial, cholinergic effect of the estrogens.This publication has 3 references indexed in Scilit:
- ACETYLCHOLINE-EQUIVALENT CONTENT OF THE UTERUS AND PLACENTA IN RABBITSAmerican Journal of Physiology-Legacy Content, 1939
- Acetylcholine content of uteri before and after administration of oestrin to ovariectomized rabbitsThe Journal of Physiology, 1939
- The activation of female sex hormonesBiochemical Journal, 1938