A new regioselective synthesis and bioactivity of 1H‐pyrazolo[3,4‐d]pyrimidin‐4(5H)‐one derivatives
- 1 May 2004
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 41 (3) , 393-397
- https://doi.org/10.1002/jhet.5570410314
Abstract
A series of new 1H‐pyrazolo[3,4‐d]pyrimidin‐4(5H)‐one Derivatives 5 has been designed and regio‐selectively synthesized via a tandem aza‐Wittig reaction. The structures of all compounds prepared have been confirmed by 1H NMR, IR, EI‐MS spectroscopy and elemental analyses. The results of preliminary bioassay indicate that most compounds 5 possess an inhibition effect against Botrytis cinereapers and Pyricularia oryzae at the concentration of 50 mg/L.Keywords
This publication has 13 references indexed in Scilit:
- A New Solution‐phase Parallel Synthesis of 2‐Alkylamino‐3‐aryl‐5‐phenylmethylene‐3,5‐dihydro‐4H‐imidazol‐4‐onesChinese Journal of Chemistry, 2003
- Synthesis and Fungicidal Activities of 4H-Imidazolin-4-ones Containing Sulfur SubstituentPhosphorus, Sulfur, and Silicon and the Related Elements, 2002
- Reactions of [(4-cyano-3-methylsulfanyl-1-phenyl)pyrazol-5-yl]iminomethylenyl Ethyl Ether with Compounds Containing Amino Group and the Bioactivity of ProductsPhosphorus, Sulfur, and Silicon and the Related Elements, 2002
- Synthesis and in vitro antifungal activity of 1‐amino‐3,4‐dialkylnaphthalene‐2‐carbonitriles and their analoguesPest Management Science, 2001
- A Facile Synthesis of 2-Mino-3H-Quinazolin-4-Ones with Tandem Aza-Wittig ReactionSynthetic Communications, 2000
- Synthesis of 3‐methyl‐substituted pyrazolotriazolopyrimidin‐4‐one and pyrazolothiazolopyrimidin‐4‐one derivativesJournal of Heterocyclic Chemistry, 1996
- A simple aza wittig‐mediated pyrimidine annulation reactionJournal of Heterocyclic Chemistry, 1991
- Synthesis of pyrazolo[3,4‐d]pyrimidine derivatives using ketene dithioacetalsJournal of Heterocyclic Chemistry, 1990
- Studies on Pyrazolo[3,4-d]pyrimidine Derivatives. XVIII. Facile Preparation of 1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-onesHETEROCYCLES, 1990
- Synthesis and in‐vitro antifungal activity of 6‐trifluoromethylpyrazolo[3,4‐d]pyrimidinesPesticide Science, 1989