Zur Vermehrung von Kernvolumen und DNS-Gehalt bei chronischer, toxisch-bedingter Leberzellschädigung

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Abstract
It was shown by fluorescent microphotometry of nuclear suspensions that the initial enlargement of the nuclei in thioacetamide-damaged liver cells in the rat runs parallel with an increase in the DNS-content. In contrast to normal liver cell nuclei the relation between nuclear volume and DNS is more variable and the increase in nuclear volume in dependence of the degree of ploidy more pronounced. In agreement with earlier studies the rise in the intermediate DNS-values is interpreted to reflect amitotic cell divisions initiated by a rhythmic increase in DNS.