IDIOTYPIC PERIPHERAL-BLOOD LYMPHOCYTES IN MONOCLONAL GAMMOPATHY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (3) , 677-682
Abstract
Using 2 sets of anti-idiotypic antibody reagents (from guinea-pig and rabbit origin), idiotypic peripheral blood lymphocytes (PBL) were shown in multiple myeloma (MM) patients in relapse, but not in remission. In patients having the benign form of monoclonal gammopathy (BMG), idiotypic lymphocytes were lacking except in some patients which were depicted as a high-risk group, by a multivariate rating system. If present, idiotypic lymphocytes accounted for 1-4% of PBL.