THE EFFECT OF CORTICOTROPIN AND CORTICOSTERONE ON THE PRODUCTION OF HEMOLYTIC ANTIBODIES IN THE MOUSE

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Abstract
It was demonstrated by quantitative immunochemical methods that corticotropin, when administered at sufficiently high levels, will suppress the formation of circulating hemolytic antibodies in the mouse; this apparent block on the antibody producing mechanism can be overcome by increasing the dose of antigen. Furthermore, it was shown that corticosterone, which appears in greater amounts in the blood of mice after treatment with corticotropin, will also suppress the normal rise of circulating immune hemolysins in the mouse.

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