LINEAR GROWTH AND PUBERTAL DEVELOPMENT IN TREATED CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY

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Abstract
21 years experience with management of seventeen cases of congenital adrenal hyperplasia due to 21‐hydroxylase deficiency has been analysed with respect to growth, bone maturation and related events at puberty: age at menarche and the occurrence of menstrual irregularities, this study showed that growth retardation is still a problem; that irregular treatment and prolonged exposure to adrenal androgens or oestrogens, may lead to disturbance in hypothalamo‐pituitary‐gonadal function and may be the cause of delayed menarche, or menstrual irregularities in the case of the female. In males the start of puberty and its completion was within the normal range.