THE ANEMIA OF INFECTION. XIII. STUDIES ON EXPERI-MENTALLY PRODUCED ACUTE HYPOFERREMIA IN DOGS AND THE RELATIONSHIP OF THE ADRENAL CORTEX TO HYPOFERREMIA 1

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Abstract
Many agents other than bacterial and sterile turpentine abscesses produce acute hypoferremia in dogs. These include histamine, epinephrine, fracture, anaphylactic shock and mild stress. The injn. of adrenocortical extract and adrenocorticotropic hormone produced a similar hypoferremia. Adrenalectomy abolished the hypoferremia produced by mild stress and by ACTH; the hypoferremia -producing effect of epinephrine was significantly reduced in the adrenalecto-mized dog but was not abolished. Intraven. administered sac-charated oxide of Fe disappeared rapidly from the plasma of intact dogs given ACTH and more slowly from the plasma of adrenalectomized dogs. The admn. of colloidal thorium dioxide also resulted in a decreased rate of disappearance of injected Fe. The intraven. injn. of Dibenamine failed to block the hypoferremia-producing effect of epinephrine and itself produced a hyperferremia maximal in 2 hrs. and a hypoferremia which began in 8 hrs. and was maximal at 24 hrs. When the various agents were employed, a correlation was observed between the degree of lymphopenia and eosinopenia produced and the degree of hypoferremia which developed.
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