Synthesis of 2-substituted primaquine analogs as potential antimalarials
- 1 September 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (9) , 995-998
- https://doi.org/10.1021/jm00207a030
Abstract
A series of 2-substituted primaquine analogues was synthesized and evaluated against Plasmodium berghei in the mouse and Leishmania donovani in the hamster. Three members of the series were evaluated against P. cynomolgi in the rhesus monkey. One analogue was evaluated against Trypanosoma rhodesiense in the mouse and 2 were evaluated against Schistosoma mansoni in the mouse. Several analogues possessed significant activity against P. berghei and L. donovani.This publication has 9 references indexed in Scilit:
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