Biological Behaviour and DNA Cytophotometry of Urothelial Bladder Carcinoma

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Abstract
In this prospective study, primary urothelial bladder tumor specimens from 64 patients were investigated by means of DNA Feulgen cytophotometry. The patients were followed clinically for at least 7 yr. The objective cytophotometric parameters correlated well with the histopathological grading and the cytochemical data were of considerable prognostic value. They were closely correlated with the stage of the tumor, 5 and 7 yr survival rates and the probability of tumor recurrence. DNA cytophotometry can serve as a method for the standardization of histological grading and can give more objective and more detailed prognostic information than conventional histopathology.