MAJOR HISTOCOMPATIBILITY COMPLEX OF CHIMPANZEES - IDENTIFICATION OF SEVERAL NEW ANTIGENS CONTROLLED BY A-LOCUS AND B-LOCUS OF CHLA

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 12  (1) , 1-18
Abstract
The serology and genetics of 17 serologically defined tissue antigens of chimpanzees is described. Analysis of their distribution in 200 unrelated chimpanzees and their segregation in a large number of chimp families suggests that 14 of the antigens are controlled by 2 closely linked loci: 7 by the A and 7 by the B locus of ChLA. Typing of chimpanzees with human alloantisera revealed that several of those A and B locus antigens of ChLA are the chimp''s serological counterparts of A and B locus antigens of the human HLA system, respectively. One of the newly discovered chimp antigens may be defined by a 3rd series of ChLA, most likely the chimp''s analogue of the human HLA-C series. The probable existence of a ChLA-linked D locus of chimpanzees and similarities between D-locus and Ia-locus (DRw) antigens of chimpanzee and man, are also briefly discussed.

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