LACTATE-DEHYDROGENASE ISOENZYMES IN NORMAL AND MALIGNANT HUMAN LYMPHOID-CELLS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (2) , 491-494
Abstract
Intracellular lactate dehydrogenase (LD) isoenzyme patterns were studied in the malignant cells of patients with a variety of lymphoid malignancies. These were compared to intracellular LD isoenzyme patterns of normal lymphoid cells and were correlated to immunologic cell surface marker characteristics. In general, the malignant B cells of Burkitt''s lymphoma and the lymphoblasts of T-cell acute lymphoblastic leukemia had isoenzyme patterns similar to those of normal B and T cells, respectively. Isoenzyme patterns of malignant lymphoid cells from patients with non-T., non-B acute lymphoblastic leukemia, cutaneous T-cell lymphoma and chronic lymphocytic leukemia were more heterogeneous. These data, although based on small numbers of patients, suggest that LD isoenzymes may reflect differences in the maturational status of cells within a single diagnostic category.