Synthesis of a C4-epi-C1−C6 Fragment of FR901464 Using a Novel Bromolactolization
- 18 September 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (21) , 3655-3658
- https://doi.org/10.1021/ol049160w
Abstract
A synthesis of a C4-epi-C1−C6 fragment of the antitumor agent FR901464 is reported. The advanced intermediate prepared in this study contains two of the three correct stereocenters found in the C1−C6 moiety of FR901464. For the preparation of this intermediate, we have developed a highly diastereoselective bromolactolization of a δ-alkenyl ketone.Keywords
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