METABOLISM OF OESTRADIOL-17β BY AN OVARIECTOMIZED EWE

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Abstract
SUMMARY: 1. A preliminary attempt has been made to assess the importance of the faecal route for the excretion of oestrogens in the sheep using a chemical method of determination. 2. Urinary excretion accounted for no more than 2% of the injected oestradiol-17β whilst the faecal excretion was calculated to be 35–40%. 3. The evidence suggests that the main metabolite in the faeces is oestradiol-17α. 4. These results help to explain the very low values for oestrogen excretion found in this species using bioassay.