Prevention of Eosinopenia in Adrenalectomized Dogs by an Antihistaminic Drug

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Abstract
A marked eosinopenia can be readily induced in adrenalectomized dogs by a variety of drugs when these are given by vein or intramuscularly in doses sufficient to elicit toxic reactions. The stress-induced decrease in eosinophils following injection of histamine, Pituitrin, epinephrine, regitine and No. 48-80 is prevented by adequate foretreatment with the antihistaminic agent, Pyribenzamine. It was observed that many of the toxic reactions exhibited by the dogs following injection of the various drugs were greatly ameloriated or prevented entirely by the antihistaminic. Pyribenzamine in the dosage employed in these experiments, was non-toxic and did not induce eosinopenia. It was ineffective in preventing the profound fall in eosinophils induced by solubilized cortisone (10% alcohol).