Unprecedented copper-catalyzed asymmetric conjugate addition of organometallic reagents to α,β-unsaturated lactams
- 28 April 2004
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 10,p. 1244-1245
- https://doi.org/10.1039/b403793f
Abstract
For the first time, an excellent enantioselectivity has been obtained in the conjugate addition of hard organometallic reagents to α,β-unsaturated lactams bearing appropriate protecting–activating groups on the nitrogen.Keywords
This publication has 20 references indexed in Scilit:
- Catalytic Enantioselective Conjugate Reduction of Lactones and LactamsJournal of the American Chemical Society, 2003
- Copper-catalyzed enantioselective conjugate addition of triethylaluminum to 2-cyclopentenoneTetrahedron: Asymmetry, 2003
- Enantioselective Copper-Catalysed Conjugate AdditionEuropean Journal of Organic Chemistry, 2002
- Stereodivergent Synthesis of Enantiopurecis- andtrans-3-Ethyl-4-piperidineacetatesOrganic Letters, 2002
- A short formal synthesis of paroxetine. Diastereoselective cuprate addition to a chiral racemic olefinic amido esterTetrahedron Letters, 2001
- Asymmetric Conjugate Additions of Chiral Phosphonamide Anions to α,β-Unsaturated Carbonyl Compounds. A Versatile Method for Vicinally Substituted ChironsThe Journal of Organic Chemistry, 2000
- Preparation of enantiopure 6-(3-indolyl)-2-piperidones and conjugate additions to a 3,4-didehydro derivativeTetrahedron, 1997
- Copper‐Catalyzed 1,4‐Additions of Trialkylaluminum Compounds to EnonesAngewandte Chemie International Edition in English, 1993
- The synthesis of aracemic 4-substituted pyrrolidinones and 3-substituted pyrrolidines. An asymmetric synthesis of (-)-rolipramThe Journal of Organic Chemistry, 1993
- Homochiral α,β-unsaturated γ-lactams: Versatile templatesTetrahedron: Asymmetry, 1992