Clinical Studies on the Relationship Between Psychosis and the Regulation of Thyroid Gland Activity

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Abstract
Thyroid function was studied longitudinally by I131 uptake and serum PBI in a chronic schizophrenic male with an alternating motility cycle. Although values were always normal, during phases characterized by muteness and retardation they were significantly higher than during hyperactive phases, when the 24-hr. I131 uptake was in the “borderline low” range. Interpretation of the coupling tentatively favored is that changes in both behavior and thyroid function are manifestations of recurring change in central nervous function involving the diencephalon and influencing pituitary secretion of thyrotrophic hormone. Urinary excretion of steroid hormones and vanilmandelic acid evidenced small but significant changes correlating with the behavioral cycle.