Effects of Corticosteroid Hormones on Regional Circulation in Endotoxin Shock.

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Abstract
Effects of prednisolone and aldosterone on regional circulation and metabolic acidosis of endotoxin shock were investigated in dogs given lethal doses of Escherichia coli lipopolysaccharide. Administration of prednisolone to the shocked animal improved mesenteric circulation; other circulatory and metabolic functions were not affected. Administration of aldosterone to the shocked animal worsened renal and mesenteric circulation as well as the metabolic acidosis. The reported survival rate improved in endotoxin shock treated with prednisolone could be related to the beneficial effects of this hormone on mesenteric circulation.